BUSINESSLocal Toxicity Studies
It refers to the study of substances that may come into contact with human skin or other mucous membranes by conducting experiments on animals. There are two well-known methods to implement this study: the skin irritation test and the eye irritation test. The skin irritation test refers to measuring the irritation of substances to skin in response to its exposure to the external factors. It usually consists of the 1st skin irritation test and consecutive skin irritation test and determine irritability in accordance with the result from observing erythema. Escher and edema. The eye irritation test, which refers to measuring the irritability of substances that may come into contact with eye mucous membrane, determine its irritability in accordance with the level of damage in cornea, iris and conjunctivae.
The Item of Trusted Research Studies(Applicable to ICH, OECD, JMHW, KFDA, NIER, RDA)
Skin irritation test
It studies the irritability of substances that may come into contact with skin, such as ointment that should be applied partially onto skin. The study conducts experiments on rabbits by applying test substances on their shavede skin to measure the partially identified irritabiliyt of substances
Eye irritation test
It studies the irritability of substances that may come into contact with eye mucous membranes(such as cornea, iris and damage of conjunctiva) It observes the partially identified irritability of substances(cornea, iris and conjunctivae) by applying test substances onto the rabbits' mucous membrane.
Other Related Item of Trusted Research Studies
- 01_ Consecutive skin irritation test
- 02_ Oral mucous membrane irritation test
- 03_ Other irritation test through different couress of medication