BUSINESS
BUSINESSLocal Toxicity Studies
Introduction
Local toxicity studies evaluate a substance for potential effects of accidental or intentional contact with human skin or mucous membranes.
The skin irritation study measures the irritation of the skin in response to exposure to a test substance. A typical study consists of a primary skin irritation test and a repeated skin irritation test, with the goal of determining irritability through observation of erythema, papule formation, and edema.
The eye irritation study measures the irritability of the eyes in response to contact with a foreign substance via the ocular mucosa. Irritability is determined according to the level of damage to the cornea, iris, and conjunctivae.
Our Studies (Applicable to ICH, OECD, JMHW, KFDA, NIER, RDA)
Skin Irritation Study
Skin irritation studies examine the irritation caused by substances that may come into contact with skin, such as topical ointments. Experiments are conducted on rabbits and involve the test substance being applied to their shaven skin in order to observe local skin irritation, such as erythema, papule formation, or edema.
Eye Irritation Study
Eye irritation studies examine the irritation caused by substances that may come into contact with the ocular mucous membranes. The test substance is applied to the ocular membranes of rabbits and local irritation is observed.
Other Available Studies
- 01_ Repeated Skin Irritation Study
- 02_ Oral Mucous Membrane Irritation Study
- 03_ Other Irritation Studies Conducted via Varied Methods of Administration