BUSINESS
BUSINESSImmunotoxicity Studies
Introduction
Immunotoxicity studies examine the potential effect of test substances on the human immune system. These studies can be used to evaluate whether various substances such as pharmaceuticals, chemicals, food, and agrochemicals can cause immune system abnormalities.
Our Studies (Applicable to ICH, OECD, JMHW, MFDS, RDA)
Active Systemic Anaphylaxis (ASA) & Passive Cutaneous Anaphylaxis (PCA)
In order to predict the potential antigenicity of a substance, this study involves repeated administration and evaluation of immunogenicity.
Skin Sensitization Studies
In order to predict the risk of skin sensitization due to the application of topical medicines, cosmetics, etc., studies can be conducted to induce an allergic response, either with or without the injection of an adjuvant.
Available tests include the maximization test, the adjuvant and patch test, the adjuvant and strip test, the Buehler test, the Draize test, the open epicutaneous test, and Freund’s complete adjuvant test.
Other Immunotoxicity Studies Using Flow Cytometry
Technology using monoclonal antibodies, which recognize specific antigens of cells, has become more widespread, and, with it, flow cytometry has found broader application. This technique allows for specific cells in a population to be separated and purified, enabling accurate interpretation by various parameters. Flow cytometry is used to study the immune cell distribution of spleen cells and the function of natural killer cells.
Other Available Studies
- 01_ Phototoxicity Test (not in the category of Immunotoxicity)
- 02_ Humoral Immunity Test
- 03_ Immunocyte Distribution Test Using Flow Cytometry
- 04_ Photo-sensitization Test
- 05_ Cell-mediated Immunity Test
- 06_ Macrophage and Natural Killer Cell Activity Assays