BUSINESS
BUSINESSPK/TK/ADME
Introduction
While pharmacokinetics deals with the interaction of the body with administered substances, such as medications or chemicals, the role of toxicokinetics is to evaluate the occurrence of toxicity in the course of administration.
The ICH has established a guideline to assess systemic exposure in toxicity studies.
Areas of Research (Applicable to OECD, JMHW, KFDA)
Pharmacokinetics
Pharmacokinetic studies evaluate the effects of a substance once it comes into contact with the body. In describing the processes involved, we use the acronym ADME: absorption, distribution, metabolism, and excretion.
Bioavailability data from these studies key in research into test substances.
HPLC, LC/MS, and LC/MS/MS analyses provide dependable, accurate results.
Toxicokinetics
We evaluate the in vivo kinetics of substances, especially concentration in the blood, to determine the extent of toxicity and to extrapolate the results to the human body.
HPLC, LC/MS, and LC/MS/MS analyses provide dependable, accurate results.
Other Available Studies
- 01_ ADME, PK, Bioavailability, & TK
- 02_ Analysis and sampling of test substance: plasma/urine/excrement/metabolomics
- 03_ Distribution studies and analysis
- 04_ Various toxicity studies along with toxicokinetic studies.
- 05_ Method development, validation, analysis