The carcinogenicity studies consist of conventional carcinogenicity studies(18 to 24 months) and short term carcinogenicity studies(6 months) which promptly examine carcinogenicity. The purpose of this study is to evaluate the carcinoflenicity of test substances in its long term exposure by providing medication during a period of time similar to the life span of test system and human. These studies usually implemented when the test substance is exposed for more than six months or the test substance is expected to contain genotoxicity and carcinooenicity. Recent studies include a short/mlddle-term carcinogenicity test using transgenic mice in consideration of budget, time and ethics for animals; thereby it has gained international acknowledgement
Biotoxtech Inc. has established peer review group abroad to acquire credibility in reading the result of histopathology. Based on the experience in both long ternm and short term carcinogenicity tests. Biotoxtech Inc. is providing the results appropriate
Trusted Research Evaluations(Applicable to OECD, JMHW, KFDS)
The carcinooenicity test using rats
By selecting test system which meets the test purposes such as wistar Hannover, F344, SDIGS rat, the test evaluates the most important carcinogenicity lision besides the category of general toxic test in the form of histopathology through oral or stuffed compound medication ofr more than 24 months.
The carcinogenicity test using mice
By selecting test system which meets the test purposes such as B6C3F1. ICR mouse, the test evaluates the most important carcinogenicity lesion besides the category of general toxic test in the form of histopathology through oral or stuffed compound medication for 18 to 24 months
The carcinogenicity test using transgenic mice
By selecting mouse models such as rasH2 TG, or p53TG. the test evaluates the most impor¬tant carcinooenicity lesion besides the category of general toxic test in the form of histopa¬thology for a short period of time (oenerally 6 months) which is less than what the standard car-cinooenicity test takes.