BUSINESS
BUSINESSReproductive & Developmental Studies
Test Introduction
The purpose of reproductiv and developmental studies is to acquire information on certain effects of human's reproductive systems when exposed to medical supplies, chemicals and pesticides, through animal experimentation.. The range of study includes overall reproduction process such as the occurrence of germ cells, coneiption, parturition, lactation. the effect on development and teratogenice of the fetus, and the evaluation of the effect on development, growth and reproductive systems of future generations While there are some differences in the way of applying test standards auch as ICH, OECD, MH, MFDA, mainly it is divided into a standard way of reproduction method and a hybrid method. Biotoxtech Inc, designs and execute a suitable test model to meet th purpose in discussion with develogers.
The Item of Trusted Research Studies(Applicable to ICH, OECD, JMHW, MFDS, NIER, RDA)
Fertility and early embryonic development study(Segment Ⅰ)
Using rodents (generally rats), the test result in response to the application of test sub-stances from pre mating to implantation is examined. In the case of female, the effect of oestrous cycles, mating. . implantation and early embryonic development is observed,whereas the spermatogenesis, sexual drive, and semen is observed in the case of male.
The embryo fetal development study(Segment Ⅱ)
The test can be implemented using rodents, (generally rats》아 non rodents (generally rab¬bits). The effect of formation can be examined such as parent body, development of embryo fetal and teratogenicity by applying the test materials from the period of implantation of embryo to hard palate closure (formation of systems). The major test categories represent the formation examina-tion of the fetus which includes the external features, internal organs and skeletal structures.
Pre and post natal development, including maternal function study((Segment Ⅲ)
Using rodents (generally rats), the effect of test substance during the period of concep-tion/lactation and its impact on conceptus and development, as well as the growth of future gener-ation can be examined by applying the test substance to the female body from implantation to lac-tation and by observing the gonatal function of future generations to check the generating delayed toxicity.